Hypercholesterolemia Impairs Transduction of Vasodilator Signals Derived From Ischemic Myocardium: Myocardium-Microvessel Cross-Talk
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چکیده
منابع مشابه
Hypercholesterolemia impairs transduction of vasodilator signals derived from ischemic myocardium: myocardium-microvessel cross-talk.
OBJECTIVE Coronary microvessels are functionally coupled to the myocardial metabolic state. In hypercholesterolemia, the coronary vascular dysfunction extends to microvascular levels. We hypothesized that the vasodilator signal transduction from ischemic heart is impaired in the coronary microvascular wall of hypercholesterolemia. METHODS AND RESULTS Rabbits were fed with normal chow (control...
متن کاملHypercholesterolemia Impairs Transduction of Vasodilator Signals Derived From Ischemic Myocardium
Objective—Coronary microvessels are functionally coupled to the myocardial metabolic state. In hypercholesterolemia, the coronary vascular dysfunction extends to microvascular levels. We hypothesized that the vasodilator signal transduction from ischemic heart is impaired in the coronary microvascular wall of hypercholesterolemia. Methods and Results—Rabbits were fed with normal chow (control g...
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REFLEX CONTROL OF cardiac function is dependent on the transduction of the sensory milieu in cardiac tissues and within major intrathoracic and cervical blood vessels. Transduction can involve mechanosensitive and/or chemosensitive inputs. Reflexes for the control of autonomic efferent outflows to the heart so engendered include the peripheral and central aspects of the cardiac nervous system. ...
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BACKGROUND Previous work has reported that coronary vasodilator reserve may persist in myocardium rendered ischemic by hypoperfusion. This study investigated the presence and extent of residual coronary vasomotor tone in myocardial regions made acutely ischemic by a flow-limiting coronary stenosis during exercise. METHODS AND RESULTS Studies were done in chronically instrumented dogs undergoi...
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ژورنال
عنوان ژورنال: Arteriosclerosis, Thrombosis, and Vascular Biology
سال: 2004
ISSN: 1079-5642,1524-4636
DOI: 10.1161/01.atv.0000143387.58166.c0